Aim: The objective of this piece is to stir rethinking about what we all have considered as established, possible, impossible, probable and improbable, about TTS and its pathophysiology and management.
Review: This communication is based on two currently published articles on takotsubo syndrome (TTS), and all its relevant literature, deliberately adopting the skeptic/critical approach of “devil’s advocate” in response to their content, exercising a self-free association mode of thinking about many of the particulars of this still elusive malady, as discussed in the two articles and also currently reflected in the literature.
Result: Many, but not all of the particulars of this still elusive malady are exprored in free-associating about all aspects of TTS.
Conclusion: What we all have considered as established, possible, impossible, probable and improbable, about TTS and its pathophysiology may need re-exploration. New, “in-box” and “out-of box” ideas may need to be pursued. To this end the present communication may be of value, by prompting us all, clinicians and investigators, to self-brain storm examining as many as possible associations about the demographic, genetic, familiar, and comorbid underpinnings, pathophysiology, diagnosis, and therapy of TTS.